adrenergic receptor antagonists การใช้

• It is an ? 1a adrenergic receptor antagonist.
• Various heterocyclic antidepressants and antipsychotics are ? 1-adrenergic receptor antagonists as well.
• Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome ( IFIS ).
• His invention of propranolol, the beta adrenergic receptor antagonist that revolutionised the medical management of angina pectoris, is considered to be one of the most important contributions to clinical medicine and pharmacology of the 20th century.
• To further make a correlation to the biochemistry ( as mentioned below ), chronic infusion of propranolol ( beta-adrenergic receptor antagonist ) prevented the behavioral changes following repeated stressor exposure thus halting long term potentiation.
• Adverse effects associated with ? 2-adrenergic receptor antagonist activity ( bronchospasm, peripheral vasoconstriction, alteration of glucose and lipid metabolism ) are less common with ? 1-selective ( often termed " cardioselective " ) agents, but receptor selectivity diminishes at higher doses.
• Other promising strategies are inhibition of interleukin 1? signaling by drugs such as VX-765; modulation of sphingosine 1-phosphate signaling by drugs such as fingolimod; activation of the mammalian target of rapamycin ( mTOR ) by drugs such as rapamycin; the hormone erythropoietin; and, paradoxically, drugs such as the ?2 adrenergic receptor antagonist atipamezole and the CB1 cannabinoid antagonist SR141716A ( rimonabant ) with proexcitatory activity.